کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2159748 1090865 2009 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Evaluation of the impact of dental artefacts on intensity-modulated radiotherapy planning for the head and neck
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Evaluation of the impact of dental artefacts on intensity-modulated radiotherapy planning for the head and neck
چکیده انگلیسی

Background and purposeHigh density materials create severe artefacts in the computed tomography (CT) scans used for radiotherapy dose calculations. Increased use of intensity-modulated radiotherapy (IMRT) to treat oropharyngeal cancers raises concerns over the accuracy of the resulting dose calculation. This work quantifies their impact and evaluates a simple corrective technique.Materials and methodsFifteen oropharyngeal patients with severe artefacts were retrospectively planned with IMRT using two different CT/density look-up tables. Each plan was recalculated using a corrected CT dataset to evaluate the dose distribution delivered to the patient. Plan quality in the absence of dental artefacts was similarly assessed. A range of dosimetric and radiobiological parameters were compared pre- and post-correction.ResultsPlans using a standard CT/density look-up table (density ⩽1.8 g/cm3) revealed inconsistent inter-patient errors, mostly within clinical acceptance, although potentially significantly reducing target coverage for individual patients. Using an extended CT/density look-up table (density ⩽10.0 g/cm3) greatly reduced the errors for 13/15 patients. In 2/15 patients with residual errors the CTV extended into the severely affected region and could be corrected by applying a simple manual correction.ConclusionsUse of an extended CT/density look-up table together with a simple manual bulk density correction reduces the impact of dental artefacts on head and neck IMRT planning to acceptable levels.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Radiotherapy and Oncology - Volume 93, Issue 3, December 2009, Pages 553–558
نویسندگان
, , ,