کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2161381 1090917 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Factors influencing bowel sparing in intensity modulated whole pelvic radiotherapy for gynaecological malignancies
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی تحقیقات سرطان
پیش نمایش صفحه اول مقاله
Factors influencing bowel sparing in intensity modulated whole pelvic radiotherapy for gynaecological malignancies
چکیده انگلیسی

Background and purposeTo evaluate the influence of uterus and bladder size on large and small bowel sparing with intensity modulated whole pelvic radiotherapy (IM-WPRT) in gynecologic patients.Patients and methodsTwenty patients were selected; 10 women with cervical cancer treated with definitive radiotherapy (group ‘DEF’) and 10 endometrial cancer patients treated postoperatively (group ‘POST’). Bladder, rectal wall, small (SB) and large bowel (LB) were delineated as organs at risk. A conformal four field technique and a seven field IMRT plan (prescription dose 50.4 Gy) were compared in terms of DVH and various target parameters.ResultsAt doses between 40 and 50.4 Gy statistically significant improvements (P<0.05) were observed for IM-WPRT for irradiated volume of rectal wall and bladder. In both patient groups, with IMRT the average irradiated volume of SB was reduced by a factor of 6 at 50.4 Gy. This ratio was 2 for LB. In the DEF group the effect of SB-sparing with IMRT correlated with bladder size (correlation coefficient 0.70) while it did not correlate in the postoperative group. The effect of LB-sparing decreased with increasing bladder size in both groups but the impact of IMRT was larger for postoperative patients.ConclusionsIMRT significantly reduced the absolute volume of rectal wall, bladder and bowel irradiated at the prescribed dose level in gynaecologic patients. Main differences between POST and DEF patients receiving IM-WPRT were absolute volumes of LB irradiated to doses between 35 and 50 Gy, suggesting an impact of intact uterus on LB volume in the pelvis. POST patients seem to benefit most from elective nodal IMRT. Bladder filling is an important co-factor influencing the benefit of IMRT with respect to OAR sparing.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Radiotherapy and Oncology - Volume 80, Issue 1, July 2006, Pages 19–26
نویسندگان
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