Topoisomerase II inhibitors

Topoisomerase II is an enzyme essential for DNA replication, chromosome condensation and chromosome segregation. Inhibitors of topoisomerase II are important drugs used in the therapy of many neoplasms including breast cancer, lung cancer, testicular cancer, lymphomas and sarcomas. This paper reviews the mechanism of action, toxicities, pharmacology and clinical use of topoisomerase II inhibitors including etoposide, teniposide, doxorubicin, daunorubicin, epirubicin, idarubicin and mitoxantrone. New information regarding these agents and on topoisomerase II inhibitors under development is highlighted.