ClC-5: Physiological role and biophysical mechanisms

- ClC-5 is an endosomal Cl−/H+ antiporter of the CLC family of ion channels and transporters.
- ClC-5 is critical for proper endocytosis.
- Mutations in ClC-5 cause Dent's disease.
- The physiological role of ClC-5 in endosomes is still unclear.
- ClC-5 has very peculiar biophysical properties.