کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2166048 | 1091809 | 2014 | 8 صفحه PDF | دانلود رایگان |
Cytosolic calcium (Cai2+) is a second messenger that is important for the regulation of secretion in many types of tissues. Bile duct epithelial cells, or cholangiocytes, are polarized epithelia that line the biliary tree in liver and are responsible for secretion of bicarbonate and other solutes into bile. Cai2+ signaling plays an important role in the regulation of secretion by cholangiocytes, and this review discusses the machinery involved in the formation of Ca2+ signals in cholangiocytes, along with the evidence that these signals regulate ductular secretion. Finally, this review discusses the evidence that impairments in cholangiocyte Ca2+ signaling play a primary role in the pathogenesis of cholestatic disorders, in which hepatic bile secretion is impaired.
Journal: Cell Calcium - Volume 55, Issue 6, June 2014, Pages 317–324