کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2166137 | 1091819 | 2013 | 8 صفحه PDF | دانلود رایگان |
The cumulus mass is a group of cells surrounding the oocyte. Cumulus cells are known to play a role in a number of reproductive events including oocyte maturation and acrosome reaction. Calcium mobilization in cumulus cells has been implicated in the process of oocyte maturation and acrosome reaction; however, its exact role remains elusive. In this review, we summarize the findings on Ca2+ mobilization in cumulus cells, with particular focus on (1) the gonadotropin/paracrine factors-induced cumulus Ca2+ mobilization and its downstream signaling pathways in oocyte maturation and (2) the sperm-derived factors-induced cumulus Ca2+ mobilization in the cross-talk between cumulus and sperm and thus acrosome reaction. The evidence suggests that as an important signaling event, Ca2+ mobilization in cumulus cells is important to germ cell development and function, and thus essential to fertilization and reproduction.
Journal: Cell Calcium - Volume 53, Issue 1, January 2013, Pages 68–75