کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2166659 1091875 2007 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Purinergic signalling and intercellular Ca2+ wave propagation in the organ of Corti
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Purinergic signalling and intercellular Ca2+ wave propagation in the organ of Corti
چکیده انگلیسی

Extracellular ATP is a key neuromodulator of visual and auditory sensory epithelia. In the rat cochlea, pharmacological dissection indicates that ATP, acting through a highly sensitive purinergic/IP3-mediated signaling pathway with (little or) no involvement of ryanodine receptors, is the principal paracrine mediator implicated in the propagation of calcium waves through supporting and epithelial cells. Measurement of sensitivity to UTP and other purinergic agonists implicate P2Y2 and P2Y4 as the main P2Y receptor isoforms involved in these responses. Ca2+ waves, elicited under highly reproducible conditions by carefully controlling dose (1 μM) and timing of focal agonist application (0.2 s), extended over radial distance greater than 160 μm from the source, identical to those activated by damaging single outer hair cells. Altogether, these results indicate that intercellular calcium waves are a robust phenomenon that confers a significant ability for cell–cell communication in the mammalian cochlea. Further ongoing research will reveal the roles that such Ca2+ waves play in the inner ear.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cell Calcium - Volume 41, Issue 1, January 2007, Pages 77–86
نویسندگان
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