Notch signaling regulates CXCR4 expression and the migration of mesenchymal stem cells

► Notch signaling affected the proliferation and differentiation of MSCs. ► Blocking Notch signaling up-regulated CXCR4 expression in MSCs. ► Blocking Notch signaling increased the MSCs migration in vitro. ► RBP-J deficient MSCs showed increased homing after hepatic I/R injury.