کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2167220 | 1092317 | 2011 | 8 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Cholecystokinin octapeptide significantly suppresses collagen-induced arthritis in mice by inhibiting Th17 polarization primed by dendritic cells Cholecystokinin octapeptide significantly suppresses collagen-induced arthritis in mice by inhibiting Th17 polarization primed by dendritic cells](/preview/png/2167220.png)
Cholecystokinin octapeptide (CCK-8) is a neuropeptide, and is shown to be a potent immunomodulator with predominant anti-inflammatory effects. Although the regulatory effect of CCK-8 on macrophages and B cells has been defined, the effect of CCK-8 on dendritic cells (DCs) and T cells is not well understood. In this study, we showed that CCK-8 reduced the expression of CD80, CD86, and MHCII on DCs. Moreover, CCK-8 promoted Th1 and inhibited Th17 polarization by increasing the production of IL-12 and decreasing the production of IL-6 and IL-23 on DCs in vitro and in vivo. In addition, intraperitoneal administration of CCK-8 to mice with collagen-induced arthritis (CIA) was found to effectively reduce the incidence of arthritis, delay its onset and prevent the occurrence of joint damage. Collectively, these results suggest that CCK-8 significantly suppresses the incidence and severity of CIA in mice, through the inhibition of DC mediated Th17 polarization.
► The effect of cholecystokinin octapeptide (CCK-8) on DC and CD4+ T cells was investigated.
► CCK-8 reduced the expression of CD80, CD86, and MHCII on DC.
► CCK-8 promoted Th1 and suppressed Th17 polarization via modulating cytokine production on DC.
► CCK-8 effectively inhibited the progression of collagen-induced arthritis (CIA).
Journal: Cellular Immunology - Volume 272, Issue 1, 2011, Pages 53–60