کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2167258 1549414 2012 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
CD19+CD1d+CD5+ B cell frequencies are increased in patients with tuberculosis and suppress Th17 responses
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
CD19+CD1d+CD5+ B cell frequencies are increased in patients with tuberculosis and suppress Th17 responses
چکیده انگلیسی

Although the importance of B cells in the host immune response upon Mycobacterium tuberculosis infection has been recognized, a conclusive role for B cells has yet to be determined. In the present study, we found that primary CD19+ B cells isolated from patients with tuberculosis significantly inhibited Th17, but not Th1, cell activation. Moreover, the suppressive activity was mediated by a CD19+CD1d+CD5+ B cell population. Notably, patients with tuberculosis were found to have significantly higher frequencies of CD19+CD1d+CD5+ B cells with stronger suppressive activity than such cells from healthy donors. Furthermore, the frequency of CD19+CD1d+CD5+ B cells in peripheral blood was inversely correlated with that of Th17 cells in patients with tuberculosis. This finding that B cells negatively regulate Th17 responses provides a novel mechanism in the regulation of CD4+ T cell responses—aside from regulatory T cells—during M. tuberculosis infection, which may impact the clinical outcome of tuberculosis.


► We examined the effect of circulating B cells on cytokines production by CD4+ T cells in TB patients.
► The CD19+CD1d+CD5+ B cells inhibit IL-17, but not IFN-γ, production by CD4+ T cells.
► The frequency of CD19+CD1d+CD5+ B cells is increased in TB patients compared to healthy donors.
► The frequency of CD19+CD1d+CD5+ B cells is inversely correlated with Th17 response in TB patients.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 274, Issues 1–2, 2012, Pages 89–97
نویسندگان
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