کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2167364 | 1549411 | 2012 | 6 صفحه PDF | دانلود رایگان |
Trichostatin A (TSA) is classical Histone deacetylase inhibitors (HDACIs) II which is used in treatment of advanced cutaneous T-cells lymphoma. Our works focused on the roles of TSA on immuno-modulatory. We found that the TSA could induce resting Teff cells into apoptotic cell death and inhibit Teff cells proliferation in a dose-dependent manner. We also observed down-regulation effects of various costimulatory/adhesion molecules on Teff cells and up-regulation of Foxp3 expression on CD4+ CD25+ T cells. Treatment with TSA could improve mice corneal allograft survival by promoting the proportions and allosuppressive function of CD4+ CD25+ regulatory T cells. Our findings suggest that the use of TSA allows the beneficial pharmacological effect on CD4+ CD25− T activation in vitro and enhancement of Foxp3+ Treg cells in vivo.
► We described the roles of Trichostatin A (TSA) on immuno-modulatory.
► TSA could induce Teff cells apoptosis and inhibit Teff cells proliferation in vitro.
► TSA could up regulate of Foxp3 expression on CD4+ CD25+ T cells in vitro.
► TSA could improve mice corneal allograft survival.
► TSA promoted the proportions and allosuppressive function of Treg cells in vivo.
Journal: Cellular Immunology - Volume 277, Issues 1–2, May–June 2012, Pages 8–13