کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2167435 | 1092332 | 2011 | 4 صفحه PDF | دانلود رایگان |
We examined whether a synthetic retinoid Am80 prevented the development of autoimmune thyroiditis in iodide-treated nonobese diabetic mice, an animal model of Hashimoto’s thyroiditis (HT). Am80 (0, 0.1 or 1 mg/kg/day) was orally administered in feed during the 8-week iodide treatment. While iodide ingestion effectively induced thyroiditis, Am80 administration failed to interfere with thyroiditis development and serum anti-thyroglobulin antibody levels regardless of the dose of the retinoid. Splenic T cell numbers, splenocyte proliferation and interferon-γ production were decreased in the Am80-treated mice. Our data suggest that Am80 is not a candidate for use in the prevention of HT.
► A synthetic retinoid Am80 was orally administered to nonobese diabetic mice.
► It failed to prevent autoimmune thyroiditis development in iodide-treated mice.
► It reduced spleen cell proliferation, T cell numbers and interferon-γ production.
► Am80 is not a candidate for use in the prevention of autoimmune thyroiditis.
Journal: Cellular Immunology - Volume 270, Issue 1, 2011, Pages 1–4