کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2167550 | 1092340 | 2010 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Discrimination between receptor- and store-operated Ca2+ influx in human neutrophils
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Discrimination between receptor- and store-operated Ca2+ influx in human neutrophils Discrimination between receptor- and store-operated Ca2+ influx in human neutrophils](/preview/png/2167550.png)
چکیده انگلیسی
Ca2+ and Sr2+ entry pathways activated by pro-inflammatory agonists FMLP, LTB4 and PAF have been compared to thapsigargin in human neutrophils. 2-APB (10 μM) increased Ca2+ influx and to a greater extent in agonist than in thapsigargin stimulated neutrophils. This action of 2-APB was specific to Ca2+ because 2-APB did not augment Sr2+ entry in agonist and thapsigargin stimulated neutrophils. This suggests that Ca2+ and Sr2+ entry can be used to discriminate between receptor and non-receptor (store)-operated Ca2+ influx. Our data show for the first time that Pyr3 whilst partially inhibiting agonist induced Ca2+ influx almost completely abolished Ca2+ influx after thapsigargin stimulation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 265, Issue 1, 2010, Pages 1-5
Journal: Cellular Immunology - Volume 265, Issue 1, 2010, Pages 1-5
نویسندگان
Michael D. Salmon, Jatinder Ahluwalia,