کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2167880 | 1549420 | 2008 | 6 صفحه PDF | دانلود رایگان |
Potential reasons for weak effects of oral tolerance in the primed immune system are still under discussion. In the present study, impacts of oral antigen uptake were studied in adoptive transfer models using T cell receptor transgenic CD4+ T cells allowing analysis of antigen-specific donor cells on single cell level. After in vivo priming and subsequent feeding, an antigen-specific delayed-type hypersensitivity reaction was sustained. Concomitantly, donor cells preferentially found in the draining lymph nodes remained at equal numbers. In contrast, adoptively transferred Th1 cells that migrated preferentially into spleen and liver became fewer upon feeding accompanied by a suppressed delayed-type hypersensitivity reaction. Thus, antigen-experienced cells did not seem to become generally resistant to tolerogenic stimuli. Our data suggest that besides a permanent inflammatory stimulus provided by the persisting antigen, diverse tissue distribution of in vivo-induced compared to adoptively transferred effector cells might interfere with oral tolerance in the experienced immune system.
Journal: Cellular Immunology - Volume 253, Issues 1–2, 2008, Pages 110–115