کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2167919 1549417 2009 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The GITRL–GITR system alters TLR-4 expression on DC during fungal infection
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
The GITRL–GITR system alters TLR-4 expression on DC during fungal infection
چکیده انگلیسی

The glucocorticoid-induced TNFR-related (GITR) protein is a member of the tumor necrosis factor receptor superfamily influencing natural and acquired immune response. GITR is activated by its ligand, GITRL, mainly expressed on antigen presenting cells. Previously, we demonstrated that GITR plays a role in regulating immune response to Candida albicans. Here we analyzed whether GITRL–GITR interaction influences the recognition of C. albicans by regulating the expression of pattern recognition receptors on splenic dendritic cells. Our report demonstrates that under physiological conditions and during candidiasis the GITRL–GITR system affects TLR-2 and TLR-4 expression on DC. These changes correlate with decrease in: MyD88 activation; CD80 and CD40 expression on DC; T cell activation response, including CD28 expression, IL-2 and IFN-γ production. Our results point out that, during fungal infection, GITRL–GITR interaction modulates TLR-4 and TLR-2 expression, thereby altering the antigen presentation process, and suggesting a role of GITRL–GITR interaction in resistance against infectious diseases.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 257, Issues 1–2, 2009, Pages 13–22
نویسندگان
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