کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2167963 | 1549422 | 2007 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Impaired thymopoiesis in interleukin-7 receptor transgenic mice is not corrected by Bcl-2
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
Murine thymocytes down-regulate IL-7 responsiveness following β-selection and reacquire sensitivity after positive selection. To assess the potential consequences of IL-7 signaling during this phase of development, transgenic IL-7 receptor alpha (IL-7Rα) mice were evaluated for IL-7 responsiveness as gauged by STAT-5 phosphorylation. Transgenic IL-7Rα expression increased the percentage of thymocytes responsive to IL-7 yet resulted in a decrease in total thymic cellularity. Aberrant thymocyte development in transgenic mice was first manifested by a reduction of DN3 thymocytes that correlated with lower Bcl-2 expression. Surprisingly, transgenic restoration of Bcl-2 expression did not correct thymic hypocellularity induced by IL-7Rα overexpression. These findings demonstrate that failure to appropriately downregulate IL-7Rα expression interferes with thymocyte development past the pro-T stage resulting in significantly lower levels of mature thymocytes.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 250, Issues 1â2, NovemberâDecember 2007, Pages 31-39
Journal: Cellular Immunology - Volume 250, Issues 1â2, NovemberâDecember 2007, Pages 31-39
نویسندگان
C. Justin Van De Wiele, Julie H. Marino, Chibing Tan, Hilary A. Kneale, John Weber, John N. Morelli, Brenda K. Davis, Ashlee A. Taylor, T. Kent Teague,