کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2168095 1092374 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
H-2 complex influences cytokine gene expression in Leishmania infantum-infected macrophages
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
H-2 complex influences cytokine gene expression in Leishmania infantum-infected macrophages
چکیده انگلیسی

This work aims to study the influence of H-2 locus in the control of Leishmania infantum infection by evaluating whether cytokine responses by host macrophages of different H-2 haplotype are differentially regulated, either induced or actively impaired during parasite growth and replication. This study shows that macrophages of “non-cure” phenotype (H-2d) are more susceptible to infection with virulent L. infantum promastigotes. Virulent parasites lead to impaired IL-12 and inhibited TNF-α expression. The degree of parasite virulence is an important contributing factor to differences detected in cytokine expression. Virulent parasites also induced TGF-β, a deactivating cytokine that is known to suppress Th-1 type responses, thus allowing the parasite to subvert antimicrobial activity and increase its chances of survival. Depending on specific host haplotype, cells differentially respond to infection since TNF-α expression is inhibited and TGF-β is enhanced by macrophages of “non-cure” phenotype, thus perhaps determining their degree of susceptibility in this strain of mice.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cellular Immunology - Volume 243, Issue 2, October 2006, Pages 118–126
نویسندگان
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