کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2168095 | 1092374 | 2006 | 9 صفحه PDF | دانلود رایگان |

This work aims to study the influence of H-2 locus in the control of Leishmania infantum infection by evaluating whether cytokine responses by host macrophages of different H-2 haplotype are differentially regulated, either induced or actively impaired during parasite growth and replication. This study shows that macrophages of “non-cure” phenotype (H-2d) are more susceptible to infection with virulent L. infantum promastigotes. Virulent parasites lead to impaired IL-12 and inhibited TNF-α expression. The degree of parasite virulence is an important contributing factor to differences detected in cytokine expression. Virulent parasites also induced TGF-β, a deactivating cytokine that is known to suppress Th-1 type responses, thus allowing the parasite to subvert antimicrobial activity and increase its chances of survival. Depending on specific host haplotype, cells differentially respond to infection since TNF-α expression is inhibited and TGF-β is enhanced by macrophages of “non-cure” phenotype, thus perhaps determining their degree of susceptibility in this strain of mice.
Journal: Cellular Immunology - Volume 243, Issue 2, October 2006, Pages 118–126