کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2168192 | 1092382 | 2006 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Prolongation of alloskin graft survival by catalytic scavengers of reactive oxygen species Prolongation of alloskin graft survival by catalytic scavengers of reactive oxygen species](/preview/png/2168192.png)
We tested the effects of salen manganese (Salen–Mn) complexes, which are scavengers of reactive oxygen species exhibiting superoxide dismutase and catalase activities on the rejection of and alloresponse to fully allogeneic skin grafts in mice. We showed that pre-transplant treatment of C57Bl/6 donor skin or of BALB/c recipients with Salen–Mn complexes significantly delayed allograft rejection. ELISPOT analysis of alloimmune response of treated mice revealed a significant reduction of the frequency of type 1 cytokine (pro-inflammatory) producing T-cells, while the number of activated T-cells producing type 2 cytokines was elevated. In addition, anti-oxidative treatment of graft recipients resulted in a profound inhibition of their donor-specific cytotoxic T-cell response. Our results indicate that salen manganese complexes mediate their effect on graft rejection both by reducing the susceptibility of graft tissue to ROS-mediated injury and by exerting an anti-inflammatory effect in recipients.
Journal: Cellular Immunology - Volume 241, Issue 2, June 2006, Pages 59–65