کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2169669 1549465 2016 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lipid unsaturation and organelle dynamics
ترجمه فارسی عنوان
اشباع لیپید و دینامیک اندرلل
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی

The number of double bonds (=unsaturation) in the acyl chains of phospholipids (PL) influences the physical properties of cellular membranes. Here, we discuss disparate molecular processes, including vesicle budding, ion channel opening, and lipoprotein formation, which are greatly facilitated by PL polyunsaturation in membranes. Experimental and computer-based approaches for the structure and dynamics of PL suggest a common cause for these effects: the ability of the polyunsaturated acyl chain of PL to extend or bent along the membrane normal according to various constraints, thereby enabling a third dimension of motion in a structure that is essentially a 2D fluid.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Cell Biology - Volume 41, August 2016, Pages 25–32
نویسندگان
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