vCLAMPs - an intimate link between vacuoles and mitochondria

Membrane contact sites connect various organelles of the cell without fusing their membranes, thus allowing the exchange of ions, metabolites and lipids across short distances between membranes that are independent of vesicular transport. Whereas ER-mitochondrial contacts are long known, contacts between the endolysosomal system and mitochondria only recently came into the limelight. Within this review, I will provide recent insights into this contact site, it's possible regulation and cellular function.