کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2169746 1093218 2013 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Wnt signaling in stem and cancer stem cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Wnt signaling in stem and cancer stem cells
چکیده انگلیسی

The functional versatility of Wnt/β-catenin signaling can be seen by its ability to act in stem cells of the embryo and of the adult as well as in cancer stem cells. During embryogenesis, stem cells demonstrate a requirement for β-catenin in mediating the response to Wnt signaling for their maintenance and transition from a pluripotent state. In adult stem cells, Wnt signaling functions at various hierarchical levels to contribute to specification of different tissues. This has raised the possibility that the tightly regulated self-renewal mediated by Wnt signaling in stem and progenitor cells is subverted in cancer cells to allow malignant progression. Intensive work is currently being performed to resolve how intrinsic and extrinsic factors that regulate Wnt/β-catenin signaling coordinate the stem and cancer stem cell states.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Cell Biology - Volume 25, Issue 2, April 2013, Pages 254–264
نویسندگان
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