کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2169787 1093220 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
A jumbo problem: mapping the structure and functions of the nuclear pore complex
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
A jumbo problem: mapping the structure and functions of the nuclear pore complex
چکیده انگلیسی

Macromolecular assemblies can be intrinsically refractive to classical structural analysis, due to their size, complexity, plasticity and dynamic nature. One such assembly is the nuclear pore complex (NPC). The NPC is formed from ∼450 copies of 30 different proteins, called nucleoporins, and is the sole mediator of exchange between the nucleus and the cytoplasm in eukaryotic cells. Despite significant progress, it has become increasingly clear that new approaches, integrating different sources of structural and functional data, will be needed to understand the functional biology of the NPC. Here, we discuss the latest approaches trying to address this challenge.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Cell Biology - Volume 24, Issue 1, February 2012, Pages 92–99
نویسندگان
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