کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2169906 1093236 2010 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Force and length regulation in the microtubule cytoskeleton: lessons from fission yeast
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Force and length regulation in the microtubule cytoskeleton: lessons from fission yeast
چکیده انگلیسی

How does a living cell deal with basic concepts of physics such as length and force? The cell has to measure distances and regulate forces to dynamically organize its interior. This is to a large extent based on microtubules (MTs) and motor proteins. Two concepts are emerging from recent studies as key to the positioning of cell components: preferred disassembly of longer MTs and preferred detachment of motors under high load force. The role of these concepts in nuclear centering and nuclear oscillations is coming to light from experimental and theoretical studies in fission yeast. These universal concepts are likely crucial for a variety of cell processes, including nuclear and mitotic spindle positioning, control of spindle length, and chromosome congression on the metaphase plate.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Cell Biology - Volume 22, Issue 1, February 2010, Pages 21–28
نویسندگان
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