کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2170231 1093258 2007 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Broken hearts, woolly hair, and tattered skin: when desmosomal adhesion goes awry
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Broken hearts, woolly hair, and tattered skin: when desmosomal adhesion goes awry
چکیده انگلیسی

Desmosomal cadherins constitute the adhesive core of desmosomes. Different desmosomal cadherins are differentially expressed in a tissue-specific as well as differentiation-dependent manner. The skin and the heart are two examples of tissues whose vital functions require the ability to endure mechanical stress, and therefore, rely on the integrity of desmosomal adhesion. When this adhesion is compromised via mutations in genes encoding desmosomal cadherins or associated plaque proteins, both tissues can suffer the consequences. Open questions revolve around whether the resulting phenotypes are solely because of physical disruption of cell adhesion or whether these events are coupled with signaling mechanisms that influence many additional cellular processes. In this review, we focus on new developments in desmosomal adhesion with an emphasis on the skin, hair, and heart.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Cell Biology - Volume 19, Issue 5, October 2007, Pages 515–520
نویسندگان
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