Molecular mechanisms of curcumins suppressing effects on tumorigenesis, angiogenesis and metastasis, focusing on NF-κB pathway

• Aberrant activation of NF-κB, has been linked with development of cancer.
• The key mechanism of NF-κB involvement in cancer pathobiology is induction of cell survival.
• Curcuminoides are a group of bioactive compounds derived from rhizomes of Curcuma longa L.
• Curcumin demonstrates its anticancer effect by suppressing NF-κB.

NF-κB pathway has long been considered as one of the potent prototypical pro-inflammatory signaling pathway and its role in several aspects of human health has been established. Recent studies have suggested that NF-κB activation is the master key in early development and pathobiology of several Cancers. Curcumin is a polyphenolic phytochemical compound with several stablished anti-inflammatory properties and is known to exert its anti-inflammatory effects mostly by interrupting NF-κB signaling pathway at multiple stages. Here we tried to provide a summary of recent finding, focusing on introducing NF-κB signaling pathways and its potential mechanism involved in development of several types of Cancers.

Summary of curcumins interfering mechanisms with NF-kB pathway.Figure optionsDownload high-quality image (177 K)Download as PowerPoint slide