کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2170465 | 1093379 | 2014 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The function of BAFF on T helper cells in autoimmunity
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The function of BAFF on T helper cells in autoimmunity The function of BAFF on T helper cells in autoimmunity](/preview/png/2170465.png)
چکیده انگلیسی
B cell-activating factor belonging to the TNF family (BAFF) exerts its pathogenic role in supporting the survival and proliferation of B cells, regulating class switch recombination as well as the selection of autoreactive B cells. Overexpression of BAFF induces a dramatic expansion of activated B cells, particularly marginal zone B cells, as well as hypergammaglobulinemia, autoantibody production and immune complex deposition. However, in addition to its effect on B cells, recent work has also demonstrated that BAFF can promote T cell activation, proliferation and differentiation. In this review, we have discussed the recent progress on the function and role of BAFF on T cells and T cell-mediated diseases.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine & Growth Factor Reviews - Volume 25, Issue 3, June 2014, Pages 301–305
Journal: Cytokine & Growth Factor Reviews - Volume 25, Issue 3, June 2014, Pages 301–305
نویسندگان
Maogen Chen, Xiaohong Lin, Ya Liu, Qiang Li, Yiling Deng, Zhongmin Liu, David Brand, Zhiyong Guo, Xiaoshun He, Bernhard Ryffel, Song Guo Zheng,