کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2170474 1093380 2014 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Lymphotoxin and TNF: How it all began—A tribute to the travelers
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Lymphotoxin and TNF: How it all began—A tribute to the travelers
چکیده انگلیسی

The journey from the discoveries of lymphotoxin (LT) and tumor necrosis factor (TNF) to the present day age of cytokine inhibitors as therapeutics has been an exciting one with many participants and highs and lows; the saga is compared to that in “The Wizard of Oz”. This communication summarizes the contributions of key players in the discovery of the cytokines and their receptors, the changes in nomenclature, and the discovery of the LT family’s crucial role in secondary and tertiary lymphoid organs. The remarkable advances in therapeutics are detailed as are remaining problems. Finally, special tribute is paid to two pioneers in the field who have recently passed away: Byron H. Waksman and Lloyd Old.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine & Growth Factor Reviews - Volume 25, Issue 2, April 2014, Pages 83–89
نویسندگان
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