کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2170534 1093384 2013 18 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Unchaining the beast; insights from structural and evolutionary studies on TGFβ secretion, sequestration, and activation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Unchaining the beast; insights from structural and evolutionary studies on TGFβ secretion, sequestration, and activation
چکیده انگلیسی

TGFβ is secreted in a latent state and must be “activated” by molecules that facilitate its release from a latent complex and allow binding to high affinity cell surface receptors. Numerous molecules have been implicated as potential mediators of this activation process, but only a limited number of these activators have been demonstrated to play a role in TGFβ mobilisation in vivo. Here we review the process of TGFβ secretion and activation using evolutionary data, sequence conservation and structural information to examine the molecular mechanisms by which TGFβ is secreted, sequestered and released. This allows the separation of more ancient TGFβ activators from those factors that emerged more recently, and helps to define a potential hierarchy of activation mechanisms.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine & Growth Factor Reviews - Volume 24, Issue 4, August 2013, Pages 355–372
نویسندگان
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