کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2170642 | 1093393 | 2011 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Does cytokine signaling link sphingolipid metabolism to host defense and immunity against virus infections? Does cytokine signaling link sphingolipid metabolism to host defense and immunity against virus infections?](/preview/png/2170642.png)
Sphingosine 1-phosphate (S1P)-metabolizing enzymes regulate the level of bioactive sphingolipids that have curative potential. Recently, S1P-metabolizing enzymes such as sphingosine kinase 1 and S1P lyase were shown to regulate influenza virus replication and the virus-induced cytopathogenicity. The mechanism appeared to employ a JAK/STAT type I interferon signaling pathway that induces anti-viral status. Further, sphingosine analogs altered cytokine responses upon influenza virus infection. This article focuses on recent discoveries about the sphingolipid system that influences on host protection from viral virulence and the involvement of cytokine signaling in its underlying mechanisms. Deciphering the steps of this pathway could help us envision how the modulation of sphingolipid metabolism can be applied as a therapeutic approach to overcome infectious diseases.
Journal: Cytokine & Growth Factor Reviews - Volume 22, Issue 1, February 2011, Pages 55–61