کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2170743 1549502 2009 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Intricacies of BMP receptor assembly
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Intricacies of BMP receptor assembly
چکیده انگلیسی

The TGF-β superfamily exhibits a feature making it distinct from many other growth factor families in that the inadequate number of ligands and receptors premises a high degree of promiscuity in ligand–receptor interaction. This highlights the importance of even small differences in affinities and specificities between different binding partners to maintain the broad spectrum of their well defined biological functions. Despite the promiscuous interactions recent data reveal differences in receptor recruitment, architectures of these assemblies and specific modulation by a multitude of extracellular as well as membrane-associated factors. These modulatory mechanisms might possibly add specificity towards defined biological functions despite the overlapping usage of receptors by various ligands.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine & Growth Factor Reviews - Volume 20, Issues 5–6, October–December 2009, Pages 367–377
نویسندگان
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