کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2170769 1093405 2010 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
IL-20: Biological functions mediated through two types of receptor complexes
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
IL-20: Biological functions mediated through two types of receptor complexes
چکیده انگلیسی

IL-20 was discovered 10 years ago as a new member of the IL-10 family of cytokines. IL-20 shares the highest amino-acid sequence identity with IL-10, IL-24 and IL-19. IL-20 is secreted by immune cells and activated epithelial cells like keratinocytes. A high expression of the corresponding IL-20 receptor chains is detected on epithelial cells. In terms of function, IL-20 might therefore mediate a crosstalk between epithelial cells and tissue-infiltrating immune cells under inflammatory conditions. Transgenic and knockout mouse models for some cytokines and receptors of the IL-10-type cytokines have provided new insights into the biology of this family. This review will focus on the biological functions of IL-20 and its receptors within the IL-10 cytokine network.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine & Growth Factor Reviews - Volume 21, Issue 5, October 2010, Pages 353–363
نویسندگان
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