کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2170841 | 1549507 | 2007 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cytokines and chemokines shaping the B-cell compartment
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cytokines and chemokines shaping the B-cell compartment Cytokines and chemokines shaping the B-cell compartment](/preview/png/2170841.png)
چکیده انگلیسی
The whole life of a B-cell from a stem cell to a mature plasma cell is governed, among other factors, by cytokines and growth factors in their microenvironment. Remarkable progress in the understanding of the mechanisms of cytokines action on the B-cell compartment was achieved by analysis of gene-targeted mice. The generation of mice deficient for individual cytokines or their receptors has shed light on the in vivo function of cytokines in B-cell responses. This review focuses on the role of cytokines in the development, maturation and differentiation of different B-cell subsets into antibody-secreting cells or memory B-cells.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine & Growth Factor Reviews - Volume 18, Issues 1–2, February–April 2007, Pages 73–83
Journal: Cytokine & Growth Factor Reviews - Volume 18, Issues 1–2, February–April 2007, Pages 73–83
نویسندگان
Eva V. Acosta-Rodríguez, Maria C. Merino, Carolina L. Montes, C. Cristina Motrán, Adriana Gruppi,