کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2170848 1549507 2007 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Cytokine-driven regulation of NK cell functions in tumor immunity: Role of the MICA-NKG2D system
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Cytokine-driven regulation of NK cell functions in tumor immunity: Role of the MICA-NKG2D system
چکیده انگلیسی

Natural killer (NK) cells are critical players during tumor growth control in immunocompetent hosts. These cells also establish a cross-talk with dendritic cells (DCs) and promote a Th1-mediated immunity. NKG2D is a pivotal receptor that directs the tumoricidal activity of NK cells through the recognition of a group of ligands such as MICA widely expressed on different tumors. Here we will review the most important tumor immune escape mechanisms that compromise the functionality of NKG2D and its cognate ligands, including TGF-β secretion, tumor shedding of soluble MICA, and additional mechanisms that compromise the tumoricidal activity of NKG2D-expressing cells. Such mechanisms may also dampen the cross-talk between NK cells and DCs during the anti-tumor immune responses. Recent knowledge may lead to innovative approaches to promote efficient NK cell-mediated anti-tumor immune responses.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine & Growth Factor Reviews - Volume 18, Issues 1–2, February–April 2007, Pages 159–170
نویسندگان
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