کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2170990 | 1549508 | 2006 | 8 صفحه PDF | دانلود رایگان |

Transforming growth factor-β (TGF-β) has been characterized as an injury-related factor, based on the observation that it is strongly up-regulated in many acute or chronic central nervous system disorders. TGF-β is generally thought to be neuroprotective and several mechanisms have been proposed to explain this beneficial action. For instance, TGF-β protects neurons against the potentiating effect of tissue-type plasminogen activator on NMDA receptor-mediated excitotoxicity, by up-regulating type-1 plasminogen activator inhibitor expression in astrocytes. TGF-β has also anti-apoptotic properties, through a recruitment of a mitogen-activated protein kinase pathway and a concomitant activation of anti-apoptotic members of the Bcl-2 family. These multiple mechanisms might reflect the pleiotropic nature of TGF-β, reinforcing the potential therapeutic value of this cytokine in several central nervous system disorders.
Journal: Cytokine & Growth Factor Reviews - Volume 17, Issues 1–2, February–April 2006, Pages 121–128