کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2170990 1549508 2006 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Transforming growth factor-β signalling in brain disorders
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Transforming growth factor-β signalling in brain disorders
چکیده انگلیسی

Transforming growth factor-β (TGF-β) has been characterized as an injury-related factor, based on the observation that it is strongly up-regulated in many acute or chronic central nervous system disorders. TGF-β is generally thought to be neuroprotective and several mechanisms have been proposed to explain this beneficial action. For instance, TGF-β protects neurons against the potentiating effect of tissue-type plasminogen activator on NMDA receptor-mediated excitotoxicity, by up-regulating type-1 plasminogen activator inhibitor expression in astrocytes. TGF-β has also anti-apoptotic properties, through a recruitment of a mitogen-activated protein kinase pathway and a concomitant activation of anti-apoptotic members of the Bcl-2 family. These multiple mechanisms might reflect the pleiotropic nature of TGF-β, reinforcing the potential therapeutic value of this cytokine in several central nervous system disorders.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine & Growth Factor Reviews - Volume 17, Issues 1–2, February–April 2006, Pages 121–128
نویسندگان
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