کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2171244 1093478 2015 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Immune reconstitution after cord blood transplantation: peculiarities, clinical implications and management strategies
ترجمه فارسی عنوان
بازسازی ایمنی پس از پیوند خون بند ناف: ویژگی ها، مفاهیم بالینی و استراتژی های مدیریت
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی

Umbilical cord blood (UCB) is now widely used as an alternative hematopoietic stem cell source for patients lacking closely matched related or unrelated adult donors. UCB transplantation has traditionally been associated with delayed engraftment, poor immune reconstitution and consequent increased risk of infection. More recent clinical studies, however, suggest that conditioning regimens and in particular the omission of in vivo T-cell depletion may play a crucial role in post-transplant T-cell expansion, facilitating a uniquely rapid immune recovery after UCB transplantation. The peculiar characteristics of UCB cells, the importance of thymic function and the role of conditioning regimens and graft-versus-host disease influencing immune reconstitution are described. The last part of the review reports available data on UCB, as well as third-party peripheral blood derived anti-viral cell therapy, which provides a novel approach to rescue UCB recipients with viral complications in the post-transplant period.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytotherapy - Volume 17, Issue 6, June 2015, Pages 711–722
نویسندگان
, , ,