کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2172442 1093543 2007 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
DC homeostasis in hematopoietic stem cell transplantation
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
DC homeostasis in hematopoietic stem cell transplantation
چکیده انگلیسی
Hematopoietic stem cell transplantation is an important experimental tool and therapeutic modality. Its efficacy and toxicity are both linked to a GvH reaction that is initiated by donor T cells recognizing recipient APC, of which DC are the most potent. In most tissues recipient DC are replaced after transplantation because they turnover rapidly from BM-derived precursors. However, in a number of sites, notably the skin, recipient DC may persist and even self-renew for many months after transplantation. Understanding the homeostasis of different APC populations and how they are related to the induction of alloreactivity may help to improve the therapeutic benefit of transplantation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytotherapy - Volume 9, Issue 6, 2007, Pages 521-531
نویسندگان
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