کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2172845 1093634 2015 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The Drosophila histone demethylase dKDM5/LID regulates hematopoietic development
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
The Drosophila histone demethylase dKDM5/LID regulates hematopoietic development
چکیده انگلیسی


• dKDM5/LID is abundant in embryonic and larval plasmatocytes.
• dKDM5/LID regulates hemocytes proliferation.
• dKDM5/LID regulates transcription factors affecting proliferation and differentiation.
• dKDM5/LID regulates some small GTPases affecting hemocytes migration.

dKDM5/LID regulates transcription of essential developmental genes and, thus, is required for different developmental processes. Here, we report the essential contribution of dKDM5/LID to hematopoiesis in Drosophila. Our results show that dKDM5/LID is abundant in hemocytes and that its depletion induces over-proliferation and differentiation defects of larval hemocytes and disrupts organization of the actin cytoskeleton. We also show that dKDM5/LID regulates expression of key factors of hematopoietic development. In particular, dKDM5/LID depletion up-regulates expression of several transcription factors involved in hemocytes proliferation and differentiation as well as of several small-GTPases that link signaling effectors to actin cytoskeleton formation and dynamics.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 405, Issue 2, 15 September 2015, Pages 260–268
نویسندگان
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