کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2172903 | 1093644 | 2015 | 11 صفحه PDF | دانلود رایگان |

• The CAM-1 and MOM-5 Wnt receptors orient the polarity of the ALM neuron.
• CAM-1 functions autonomously in the ALM neuron to orient its polarity.
• CAM-1 also functions non-autonomously to antagonize Wnt signaling.
• This antagonistic function can mask CAM-1's autonomous role as a Wnt receptor.
Wnts are a conserved family of secreted glycoproteins that regulate various developmental processes in metazoans. Three of the five Caenorhabditis elegans Wnts, CWN-1, CWN-2 and EGL-20, and the sole Wnt receptor of the Ror kinase family, CAM-1, are known to regulate the anterior polarization of the mechanosensory neuron ALM. Here we show that CAM-1 and the Frizzled receptor MOM-5 act in parallel pathways to control ALM polarity. We also show that CAM-1 has two functions in this process: an autonomous signaling function that promotes anterior polarization and a nonautonomous Wnt-antagonistic function that inhibits anterior polarization. These antagonistic activities can account for the weak ALM phenotypes displayed by cam-1 mutants. Our observations suggest that CAM-1 could function as a Wnt receptor in many developmental processes, but the analysis of cam-1 mutants may fail to reveal CAM-1's role as a receptor in these processes because of its Wnt-antagonistic activity. In this model, loss of CAM-1 results in increased levels of Wnts that act through other Wnt receptors, masking CAM-1's autonomous role as a Wnt receptor.
Journal: Developmental Biology - Volume 404, Issue 1, 1 August 2015, Pages 55–65