Placental PPARγ regulates spatiotemporally diverse genes and a unique metabolic network

► Placental PPARγ targets identified by integrating multiple regulatory paradigms. ► Placental PPARγ-regulated genes are spatially and temporally diverse. ► NCOA6, but not MED1, co-regulates a substantial cohort of placental PPARγ targets. ► Ldhb is a direct target and part of a metabolic pathway regulated by placental PPARγ.