Elf5 regulation in the Trophectoderm

► Elf5 expression in TE does not require a region showing differential methylation. ► Elf5 expression in the trophectoderm is driven by two redundant enhancers. ► The TE enhancers are not conserved in mammals. ► In cattle Elf5 is not expressed in the TE but rather in the embryonic disc.