کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2173890 1093758 2010 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Perturbation analysis analyzed—mathematical modeling of intact and perturbed gene regulatory circuits for animal development
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Perturbation analysis analyzed—mathematical modeling of intact and perturbed gene regulatory circuits for animal development
چکیده انگلیسی

Gene regulatory networks for animal development are the underlying mechanisms controlling cell fate specification and differentiation. The architecture of gene regulatory circuits determines their information processing properties and their developmental function. It is a major task to derive realistic network models from exceedingly advanced high throughput experimental data. Here we use mathematical modeling to study the dynamics of gene regulatory circuits to advance the ability to infer regulatory connections and logic function from experimental data. This study is guided by experimental methodologies that are commonly used to study gene regulatory networks that control cell fate specification. We study the effect of a perturbation of an input on the level of its downstream genes and compare between the cis-regulatory execution of OR and AND logics. Circuits that initiate gene activation and circuits that lock on the expression of genes are analyzed. The model improves our ability to analyze experimental data and construct from it the network topology. The model also illuminates information processing properties of gene regulatory circuits for animal development.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 344, Issue 2, 15 August 2010, Pages 1110–1118
نویسندگان
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