کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2174430 1093796 2008 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Foxo3 is a PI3K-dependent molecular switch controlling the initiation of oocyte growth
چکیده انگلیسی

In mammals, oocytes are packaged into compact structures–primordial follicles–which remain inert for prolonged intervals until individual follicles resume growth via a process known as primordial follicle activation. Here we show that the phosphoinositide 3-kinase (PI3K) signalling pathway controls primordial follicle activation through the forkhead transcription factor Foxo3. Within oocytes, Foxo3 is regulated by nucleocytoplasmic shuttling. Foxo3 is imported into the nucleus during primordial follicle assembly, and is exported upon activation. Oocyte-specific ablation of Pten resulted in PI3K-induced Akt activation, Foxo3 hyperphosphorylation, and Foxo3 nuclear export, thereby triggering primordial follicle activation, defining the steps by which the PI3K pathway and Foxo3 control this process. Inducible ablation of Pten and Foxo3 in adult oocytes using a new tool for genetic analysis of the germline, Vasa-CreERT2, showed that this pathway functions throughout life. Thus, a principal physiologic role of the PI3K pathway is to control primordial follicle activation via Foxo3.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 321, Issue 1, 1 September 2008, Pages 197–204
نویسندگان
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