کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2174482 1093803 2008 13 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The MIG-15 NIK kinase acts cell-autonomously in neuroblast polarization and migration in C. elegans
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
The MIG-15 NIK kinase acts cell-autonomously in neuroblast polarization and migration in C. elegans
چکیده انگلیسی

Cell migration is a fundamental process in animal development, including development of the nervous system. In C. elegans, the bilateral QR and QL neuroblasts undergo initial anterior and posterior polarizations and migrations before they divide to produce neurons. A subsequent Wnt signal from the posterior instructs QL descendants to continue their posterior migration. Nck-interacting kinases (NIK kinases) have been implicated in cell and nuclear migration as well as lamellipodia formation. Studies here show that the C. elegans MIG-15 NIK kinase controls multiple aspects of initial Q cell polarization, including the ability of the cells to polarize, to maintain polarity, and to migrate. These data suggest that MIG-15 acts independently of the Wnt signal that controls QL descendant posterior migration. Furthermore, MIG-15 affects the later migrations of neurons generated from Q cell division. Finally, a mosaic analysis indicates that MIG-15 acts cell-autonomously in Q descendant migration.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 324, Issue 2, 15 December 2008, Pages 245–257
نویسندگان
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