کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2174568 | 1093809 | 2008 | 8 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Nitric oxide, C-type natriuretic peptide and cGMP as regulators of endochondral ossification
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Nitric oxide, C-type natriuretic peptide and cGMP as regulators of endochondral ossification Nitric oxide, C-type natriuretic peptide and cGMP as regulators of endochondral ossification](/preview/png/2174568.png)
چکیده انگلیسی
Coordinated proliferation and differentiation of growth plate chondrocytes is required for endochondral bone growth, but the mechanisms and pathways that control these processes are not completely understood. Recent data demonstrate important roles for nitric oxide (NO) and C-type natriuretic peptide (CNP) in the regulation of cartilage development. Both NO and CNP stimulate the synthesis of cGMP and thus the activation of common downstream pathways. One of these downstream mediators, cGMP-dependent kinase II (cGKII), has itself been shown to be essential for normal endochondral bone formation. This review summarizes our knowledge of the roles and mechanisms of NO, CNP and cGKII signaling in cartilage and endochondral bone development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 319, Issue 2, 15 July 2008, Pages 171–178
Journal: Developmental Biology - Volume 319, Issue 2, 15 July 2008, Pages 171–178
نویسندگان
Cristina C. Teixeira, Hanga Agoston, Frank Beier,