کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2175110 1093832 2007 17 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Pax–Six–Eya–Dach network during amphioxus development: Conservation in vitro but context specificity in vivo
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Pax–Six–Eya–Dach network during amphioxus development: Conservation in vitro but context specificity in vivo
چکیده انگلیسی

The Drosophila retinal determination gene network occurs in animals generally as a Pax–Six–Eyes absent–Dachshund network (PSEDN). For amphioxus, we describe the complete network of nine PSEDN genes, four of which–AmphiSix1/2, AmphiSix4/5, AmphSix3/6, and AmphiEya–are characterized here for the first time. For amphioxus, in vitro interactions among the genes and proteins of the network resemble those of other animals, except for the absence of Dach–Eya binding. Amphioxus PSEDN genes are expressed in highly stage- and tissue-specific patterns (sometimes conspicuously correlated with the local intensity of cell proliferation) in the gastrular organizer, notochord, somites, anterior central nervous system, peripheral nervous system, pharyngeal endoderm, and the likely homolog of the vertebrate adenohypophysis. In this last tissue, the anterior region expresses all three amphioxus Six genes and is a zone of active cell proliferation, while the posterior region expresses only AmphiPax6 and is non-proliferative. In summary, the topologies of animal PSEDNs, although considerably more variable than originally proposed, are conserved enough to be recognizable among species and among developing tissues; this conservation may reflect indispensable involvement of PSEDNs during the critically important early phases of embryology (e.g. in the control of mitosis, apoptosis, and cell/tissue motility).

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 306, Issue 1, 1 June 2007, Pages 143–159
نویسندگان
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