کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2176123 1093863 2006 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
MAU-8 is a Phosducin-like Protein required for G protein signaling in C. elegans
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
MAU-8 is a Phosducin-like Protein required for G protein signaling in C. elegans
چکیده انگلیسی

The mau-8(qm57) mutation inhibits the function of GPB-2, a heterotrimeric G protein β subunit, and profoundly affects behavior through the Gαq/Gαo signaling network in C. elegans. mau-8 encodes a nematode Phosducin-like Protein (PhLP), and the qm57 mutation leads to the loss of a predicted phosphorylation site in the C-terminal domain of PhLP that binds the Gβγ surface implicated in membrane interactions. In developing embryos, MAU-8/PhLP localizes to the cortical region, concentrates at the centrosomes of mitotic cells and remains associated with the germline blastomere. In adult animals, MAU-8/PhLP is ubiquitously expressed in somatic tissues and germline cells. MAU-8/PhLP interacts with the PAR-5/14.3.3 protein and with the Gβ subunit GPB-1. In mau-8 mutants, the disruption of MAU-8/PhLP stabilizes the association of GPB-1 with the microtubules of centrosomes. Our results indicate that MAU-8/PhLP modulates G protein signaling, stability and subcellular location to regulate various physiological functions, and they suggest that MAU-8 might not be limited to the Gαq/Gαo network.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 294, Issue 1, 1 June 2006, Pages 181–191
نویسندگان
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