کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2176204 1093866 2006 9 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
The role of the laminin β subunit in laminin heterotrimer assembly and basement membrane function and development in C. elegans
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
The role of the laminin β subunit in laminin heterotrimer assembly and basement membrane function and development in C. elegans
چکیده انگلیسی

Laminins are components of basement membranes that are required for morphogenesis, organizing cell adhesions and cell signaling. Studies have suggested that laminins function as αx βy γz heterotrimers in vivo. In C. elegans, there is only one laminin β gene, suggesting that it is required for all laminin functions. Our analysis is consistent with the role of the laminin β as a subunit of laminin heterotrimers; the same cells express the laminin α, β, and γ subunits, the laminin β subunit localizes to all basement membranes throughout development, and secretion of the β subunit requires an α subunit. RNAi inhibition of the β subunit gene or of the other subunit genes causes an embryonic lethality phenotype. Furthermore, a distinctive set of phenotypes is caused by both viable laminin α and β partial loss-of-function mutations. These results show developmental roles for the laminin β subunit, and they provide further genetic evidence for the importance of heterotrimer assembly in vivo.

ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 290, Issue 1, 1 February 2006, Pages 211–219
نویسندگان
, , , , ,