کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
2176658 1094561 2014 14 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
An Enhancer Composed of Interlocking Submodules Controls Transcriptional Autoregulation of Suppressor of Hairless
ترجمه فارسی عنوان
تقویت کننده ای از زیرمویل های متصل می شود کنترل تنظیمات تروریستی از سرکوب کننده ناخن
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
چکیده انگلیسی


• An autoregulatory enhancer is composed of functionally separable submodules
• Autoregulation is subject to dynamic combinatorial control
• Interlinked positive-feedback loops establish rapid and irreversible autoregulation
• A transcription factor threshold level is essential for the autoregulatory state

SummaryPositive autoregulation is an effective mechanism for the long-term maintenance of a transcription factor’s expression. This strategy is widely deployed in cell lineages, where the autoregulatory factor controls the activity of a battery of genes that constitute the differentiation program of a postmitotic cell type. In Drosophila, the Notch pathway transcription factor Suppressor of Hairless activates its own expression, specifically in the socket cell of external sensory organs, via an autoregulatory enhancer called the ASE. Here, we show that the ASE is composed of several enhancer submodules, each of which can independently initiate weak Su(H) autoregulation. Cross-activation by these submodules is critical to ensure that Su(H) rises above a threshold level necessary to activate a maintenance submodule, which then sustains long-term Su(H) autoregulation. Our study reveals the use of interlinked positive-feedback loops to control autoregulation dynamically and provides mechanistic insight into initiation, establishment, and maintenance of the autoregulatory state.

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ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: - Volume 29, Issue 1, 14 April 2014, Pages 88–101
نویسندگان
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