کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
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2176901 | 1094596 | 2013 | 9 صفحه PDF | دانلود رایگان |
SummaryIn Drosophila, left/right (LR) asymmetry is apparent in the directional looping of the gut and male genitalia. The dextral orientation of the organs depends on the activity of a single gene, MyosinID (myoID), whose mutation leads to a fully inverted LR axis, thus revealing the activity of a recessive sinistral pathway. Here, we present the identification of the Hox gene Abdominal-B (Abd-B) as an upstream regulator of LR determination. This role appears distinct from its function in anteroposterior patterning. We show that the Abd-Bm isoform binds to regulatory sequences of myoID and controls MyoID expression in the organ LR organizer. Abd-Bm is also required for the sinistral pathway. Thus, when Abd-B activity is missing, no symmetry breaking occurs and flies develop symmetrically. These findings identify the Hox gene Abd-B as directing the earliest events of LR asymmetry establishment in Drosophila.
Graphical AbstractFigure optionsDownload high-quality image (217 K)Download as PowerPoint slideHighlights
► Abd-B directs the earliest steps of Drosophila left/right asymmetry establishment
► Abd-B directly regulates expression of the dextral determinant-encoding gene myoID
► Abd-B controls the two opposite dextral and sinistral left/right pathways
► Abd-B absence leads to the symmetrical development of normally asymmetric organs
Journal: - Volume 24, Issue 1, 14 January 2013, Pages 89–97