کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
2177029 | 1094618 | 2008 | 7 صفحه PDF | دانلود رایگان |
![عکس صفحه اول مقاله: Myosin II Activity Facilitates Microtubule Bundling in the Neuronal Growth Cone Neck Myosin II Activity Facilitates Microtubule Bundling in the Neuronal Growth Cone Neck](/preview/png/2177029.png)
SummaryThe cell biological processes underlying axon growth and guidance are still not well understood. An outstanding question is how a new segment of the axon shaft is formed in the wake of neuronal growth cone advance. For this to occur, the highly dynamic, splayed-out microtubule (MT) arrays characteristic of the growth cone must be consolidated (bundled together) to form the core of the axon shaft. MT-associated proteins stabilize bundled MTs, but how individual MTs are brought together for initial bundling is unknown. Here, we show that laterally moving actin arcs, which are myosin II-driven contractile structures, interact with growing MTs and transport them from the sides of the growth cone into the central domain. Upon Myosin II inhibition, the movement of actin filaments and MTs immediately stopped and MTs unbundled. Thus, Myosin II-dependent compressive force is necessary for normal MT bundling in the growth cone neck.
Journal: - Volume 15, Issue 1, 8 July 2008, Pages 163–169